DIANA BAUTISTADissecting the precise nature of itch-evoked scratching
Wimalasena N, Milner G, Silva R, Vuong C, Zhang Z, Bautista DM, Woolf CJ. Neuron. 2021 October 6;109(19):3075-3087. doi: 10.1016/j.neuron.2021.07.020 Nerve-associated transient receptor potential ion channels can contribute to intrinsic resistance to bacterial adhesion in vivo Wan SJ, Datta A, Flandrin O, Metruccio MME, Ma S, Nieto V, Kroken AR, Hill RZ, Bautista DM, Evans DJ, Fleiszig SMJ. The FASEB Journal. 2021 September 27;35(10). doi: 10.1096/fj.202100874R Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG. Nature Structural & Molecular Biology. 2021 June 22;28:573-582. doi: 10.1038/s41594-021-00619-0 Loss of S1PR3 attenuates scratching behaviors in mice in the imiquimod model of psoriasis, but not in the MC903 model of atopic dermatitis Hill RZ, Rifi Z, Vuong, C, Bautista DM. Itch. 2020 Apr 7; http://dx.doi.org/10.1097/itx.0000000000000035 Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. Walsh CM, Hill RZ, Schwendinger-Schreck J, Deguine J, Brock EC, Kucirek N, Rifi Z, Wei J, Gronert K, Brem RB, Barton GM, Bautista DM. Elife. 2019 Oct 21;8. pii: e48448. doi: 10.7554/eLife.48448. Optical control of sphingosine-1-phosphate formation and function. Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D. Nature Chemical Biology. 2019 Apr 29;7. doi: 10.1038/s41589-019-0269-7. S1PR3 mediates itch and pain via distinct TRP channel-dependent pathways. Hill RZ, Morita T, Brem RB, Bautista DM. Journal of Neuroscience. 2018 Aug 6;7. doi: 10.1523/JNEUROSCI. 1266-18.2018. The Signaling Lipid Sphingosine 1-Phosphate Regulates Mechanical Pain. Hill RZ, Hoffman BU, Morita T, Campos SM, Lumpkin EA, Brem RB, Bautista DM. Elife. 2018 Mar 21;7. doi: 10.7554/eLife.33285. Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor McGourty CA, Akopian D, Walsh C, Gorur A, Werner A, Schulman R,, Bautista D, Rape M. Cell. 2016 Oct 6;167(2):525-538. Unconventional endocannabinoid signaling governs sperm activation via sex hormone progesterone. Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV. Science. 2016 Apr 29;352(6285):555-9 HTR7 Mediates Serotonergic Acute and Chronic Itch. Morita T, McClain SP, Batia LM, Pellegrino M, Wilson SR, Kienzler MA, Lyman K, Olsen AS, Wong JF, Stucky CL, Brem RB, Bautista DM. Neuron. 2015 Jul 1;87(1):124-38. The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch. Wilson SR, Thé L, Batia LM, Beattie K, Katibah GE, McClain SP, Pellegrino M, Estandian DM, Bautista DM. Cell. 2013 Oct 10;155(2):285-295. A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. Tsunozaki M, Lennertz RC, Vilceanu D, Katta S, Stucky CL, Bautista DM. J Physiol. 2013 Jul 1;591(Pt 13):3325-40. The ion channel TRPA1 is required for chronic itch. Wilson SR, Nelson AM, Batia L, Morita T, Estandian D, Owens DM, Lumpkin EA, Bautista DM.J Neurosci. 2013 May 29;33(22):9283-94. The star-nosed mole reveals clues to the molecular basis of mammalian touch. Gerhold KA, Pellegrino M, Tsunozaki M, Morita T, Leitch DB, Tsuruda PR, Brem RB, Catania KC, Bautista DM. PLoS One. 2013;8(1):e55001. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. Almeida MC, Hew-Butler T, Soriano RN, Rao S, Wang W, Wang J, Tamayo N, Oliveira DL, Nucci TB, Aryal P, Garami A, Bautista D, Gavva NR, Romanovsky AA. J Neurosci. 2012 Feb 8;32(6):2086-99. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM. Nat Neurosci. 2011 May;14(5):595-602. Biophysical regulation of histone acetylation in mesenchymal stem cells. Li Y, Chu JS, Kurpinski K, Li X, Bautista DM, Yang L, Sung KL, Li S. Biophys J. 2011 Apr 20;100(8):1902-9. TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Knowlton WM, Bifolck-Fisher A, Bautista DM, McKemy DD. Pain. 2010 Aug;150(2):340-50. Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool. Lennertz RC, Tsunozaki M, Bautista DM, Stucky CL. J Neurosci. 2010 Mar 24;30(12):4353-61. ReviewsBasophils add fuel to the flame of eczema itch.
Mali SS, Bautista DM. Cell. 2021 Jan 21;184(2):294-296. doi: 10.1016/j.cell.2020.12.035. Getting in touch with mechanical pain mechanisms. Hill RZ, Bautista DM. Trends in Neuroscience. 2020 May;43(5):311-325. doi: 10.1016/j.tins.2020.03.004. A TREK to Translate Genetics to Mechanisms of Migraine. Hill RZ, Bautista DM. Neuron. 2019 Jan 16;193-195. doi: 10.1016/j.neuron.2018.12.034. A trio of ion channels takes the heat. Hill RZ, Bautista DM. Nature. 2018 Mar 29;555(7698):591-592. doi: 10.1038/d41586-018-02663-1. Mammalian touch catches up. Walsh CM, Bautista DM, Lumpkin EA. Curr Opin Neurobiol. 2015 Oct;34:133-9. doi: 10.1016/j.conb.2015.05.003. Epub 2015 Jun 19. Review. Interactions between keratinocytes and somatosensory neurons in itch. Schwendinger-Schreck J, Wilson SR, Bautista DM. Handbook of Exp Pharm. 2015 226(10):177-190. Why we scratch an itch: the molecules, cells and circuits of itch. Bautista DM, Wilson SR, Hoon MA. Nat Neurosci. 2014 Feb;17(2):175-82. Itching for relief. Wilson S, Bautista D. Nat Neurosci. 2013 Jun 25;16(7):775-7. TRPA1: A gatekeeper for inflammation. Bautista DM, Pellegrino M, Tsunozaki M. Annu Rev Physiol. 2013;75:181-200. Perspectives on: information and coding in mammalian sensory physiology: probing mammalian touch transduction. Bautista DM, Lumpkin EA. J Gen Physiol. 2011 Sep;138(3):291-301. Cellular and molecular mechanisms of pain. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cell. 2009 Oct 16;139(2):267-84. Mammalian somatosensory mechanotransduction. Tsunozaki M, Bautista DM. Curr Opin Neurobiol. 2009 Aug;19(4):362-9. Molecular and cellular mechanisms of trigeminal chemosensation. Gerhold KA, Bautista DM. Ann N Y Acad Sci. 2009 Jul;1170:184-9. TRPA1: irritant detector of the airways. Gerhold KA, Bautista DM. J Physiol. 2008 Jul 15;586(14):3303. Further publications
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ELLEN LUMPKINHealthy human laryngopharyngeal sensory innervation density correlates with age.
Cole CL, Yu VX, Perry S, Seenauth A, Lumpkin EA, Troche MS, Pitman MJ, Moayedi Y. Laryngoscope. 2022 Jul 16. doi: 10.1002/lary.30287. Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2 Hoffman, BU, Baba Y, Lee SA, Tong CK, Konafagou EE, Lumpkin EA. Proc Nat Acad Sci USA. 2022 May 24;119(21):e2115821119. doi: 10.1073/pnas.2115821119. Engineering human skin model innervated with itch sensory neuron-like cells differentiated from induced pluripotent stem cells Guo Z, Tong CK, Jacków J, Doucet YS, Abaci HE, Zeng W, Hansen C, Hayashi R, DeLorenzo D, Rami A, Pappalardo A, Lumpkin EA, Christiano AM. Bioeng Transl Med. 2021 Aug 20;7(1):e10247. doi: 10.1002/btm2.10247. Somatosensory innervation of healthy human oral tissues Moayedi Y, Michlig S, Park M, Koch A, Lumpkin EA. J Comp Neurol. 2021 Aug 1;529(11):3046-3061. doi: 10.1002/cne.25148. Tetrodotoxin-sensitive sodium channels mediate action potential firigina dn excitability in menthol-sensitive Vglut3-lineage sensory neurons Griffith TN, Docter T, Lumpkin EA. J Neurosci. 2019 Sep 4;39(36):7086-7101. doi: 10.1523/JNEUROSCI.2817-18.2019. The cellular basis of mechanosensory Merkel-cell innervation during development Jenkins BA, Fontecilla NM, Lu CP, Fuchs E, Lumpkin EA. Elife. 2019 Feb 22;8:e42633. doi: 10.7554/eLife.42633. Camphor white oil induces tumor regression through cytotoxic T cell-dependent mechanisms Moayedi Y, Greenberg SA, Jenkins BA, Marshall KL, Dimitrov LV, Nelson AM, Owens DM, Lumpkin EA. Mol Carcinog. 2019 May;58(5):722-734. doi: 10.1002/mc.22965. Merkel cells activate sensory neural pathways through adrenergic synapses Hoffman BU, Baba Y, Griffith TN, Mosharov EV, Woo SH, Roybal DD, Karsenty, G, Patapoutian A, Sulzer D, Lumpkin EA. Neuron. 2018 Dec 19;100(6):1401-1413.e6. doi: 10.1016/j.neuron.2018.10.034. Somatosensory innervation of the oral mucosa of adult and aging mice Moayedi Y, Duenas-Bianchi LF, Lumpkin EA. Sci Rep. 2018 Jul 2;8(1):9975. doi: 10.1038/s41598-018-28195-2. Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes Gerling GJ, Wan L, Hoffman BU, Wang Y, Lumpkin EA. PLoS Comput Biol. 2018 Jun 29;14(6):e1006264. doi: 10.1371/journal.pcbi.1006264. The Signaling Lipid Sphingosine 1-Phosphate Regulates Mechanical Pain. Hill RZ, Hoffman BU, Morita T, Campos SM, Lumpkin EA, Brem RB, Bautista DM. Elife. 2018 Mar 21;7. doi: 10.7554/eLife.33285. Touch receptors undergo rapid remodeling in healthy skin Marshall KL, Clary RC, Baba Y, Orlowsky RL, Gerling GJ, Lumpkin EA. Cell Rep. 2016 Nov 8;17(7):1719-1727. doi: 10.1016/j.celrep.2016.10.034. Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Wang Y, Baba Y, Lumpkin EA, Gerling GJ. J Neurophysiol. 2016 Jul 1;116(1):218-28. doi: 10.1152/jn.00624.2015. Somatosensory substrates of flight control in bats Marshall KL, Chadha M, deSouza LA, Sterbing-D'Angelo S, Moss CF, Lumpkin EA. Cell Rep. 2015 May 12;11(6):851-858. doi: 10.1016/j.celrep.2015.04.001. Compressive viscoelasticity of freshly excised mouse skin is dependent on specimen thickness, strain level and rate Wang Y, Marshall KL, Baba Y, Lumpkin EA, Gerling GJ. PLoS One. 2015 Mar 24;10(3):e0120897. doi: 10.1371/journal.pone.0120897. Piezo2 is required for Merkel cell mechanotransduction Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A. Nature. 2014 May 29;509(7502):622-6. doi: 10.1038/nature13251 Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors Maksimovic S, Nakatani M, Baba Y, Nelson AM, Marshall KL, Wellnitz SA, Firozi P, Woo SH, Ranade S, Patapoutian A, Lumpkin EA. Nature. 2014 May 29;509(7502):617-21. doi: 10.1038/nature13250. Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors Lesniak DR, Marshall KL, Wellnitz SA, Jenkins BA, Baba Y, Rasband MN, Gerling GJ, Lumpkin EA. Elife. 2014;3:e01488. doi: 10.7554/eLife.01488. Natural variation in skin thickness argues for mechanical stimulus control by force instead of displacement Wang Y, Marshall KL, Baba Y, Lumpkin EA, Gerling GJ. World Haptics Conf. 2013;2013:645-650. doi: 10.1109/WHC.2013.6548484. Hyperelastic material properties of mouse skin under compression. Wang Y, Marshall KL, Baba Y, Lumpkin EA, Gerling GJ. PLoS One. 2013 Jun 18;8(6):e67439. doi: 10.1371/journal.pone.0067439. The ion channel TRPA1 is required for chronic itch. Wilson SR, Nelson AM, Batia L, Morita T, Estandian D, Owens DM, Lumpkin EA, Bautista DM. J Neurosci. 2013 May 29;33(22):9283-94. Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor. Woo SH, Baba Y, Franco AM, Lumpkin EA, Owens DM. Development. 2012 Feb;139(4):740-8. doi: 10.1242/dev.070847. Identification of epidermal progenitors for the Merkel cell lineage Woo SH, Stumpfova M, Jensen UB, Lumpkin EA, Owens DM. Development. 2010 Dec;137(23):3965-71. doi: 10.1242/dev.055970. ReviewsDeveloping a sense of touch
Jenkins BA, Lumpkin EA. Development. 2017 Nov 15;144(22):4078-4090. doi: 10.1242/dev.120402. Mammalian touch catches up. Walsh CM, Bautista DM, Lumpkin EA. Curr Opin Neurobiol. 2015 Oct;34:133-9. doi: 10.1016/j.conb.2015.05.003. Epub 2015 Jun 19. Review. Merkel cells and neurons keep in touch. Woo SH, Lumpkin EA, Patapoutian A. Trends Cell Biol. 2015 Feb;25(2):74-81. doi: 10.1016/j.tcb.2014.10.003. Mechanotransduction in epidermal Merkel cells Nakatani M, Maksimovic S, Baba Y, Lumpkin EA. Pflugers Arch. 2015 Jan;467(1):101-8. doi: 10.1007/s00424-014-1569-0. Diversification and specialization of touch receptors in skin. Owens D, Lumpkin EA. Cold Spring Hard Perspect Med. 2014 Jun 2;4(6):a013656. doi: 10.1101/cshperspect.a013656. The molecular basis of mechanosensory transduction Marshall KL, Lumpkin EA. Adv Exp Med Biol. 2012;739:142-55. doi: 10.1007/978-1-4614-1704-0_9. The cell biology of touch Lumpkin EA, Marshall KL, Nelson MA. J Cell Biol. 2010 Oct 18;191(2):237-48. doi: 10.1083/jcb.201006074. |
